DTAlfred CollinsOutSep 9: Collins will miss the entire 2026 season after suffering a torn patellar tendon during Tuesday's practice, Nick Wagoner of ESPN.com reports.02/15/2027 WRBrandon AiyukOutSep 21: Head coach Kyle Shanahan said Sunday that he's not viewing Aiyuk as an option for the 49ers while the club contends with multiple injuries at receiver, Matt Barrows of The Athletic reports.02/15/2027 WRDe'Zhaun StriblingOutSep 16: The 49ers are expected to place Stribling (ankle) on injured reserve, Adam Schefter of ESPN.com reports.11/22/2026 WRDemarcus RobinsonOutSep 21: San Francisco head coach Kyle Shanahan said that Robinson is facing a recovery timeline of 3-to-6 weeks after sustaining a high-ankle sprain in Sunday's 35-13 win over the Dolphins, Nick Wagoner of ESPN.com reports.10/11/2026 RBIsaac GuerendoOutAug 30: Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.11/08/2026 OTNick ZakeljIRAug 31: Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday.02/15/2027 DTSam OkuayinonuOutSep 3: Okuayinonu (foot) will not travel with the team to Melbourne, Australia ahead of the Week 1 game versus the Rams, Nick Wagoner of ESPN.com reports.09/20/2026 RBChristian McCaffreyQuestionableOct 26: McCaffrey is dealing with a mild hamstring strain rather than a quadriceps injury, and the 49ers believe he'll be ready following the team's Week 8 bye, David Lombardi of SF Standard reports.11/08/2026 WRDeebo Samuel Sr.QuestionableOct 26: Samuel (hamstring) has a chance to return following the 49ers' Week 8 bye, Matt Maiocco of NBC Sports Bay Area reports.11/08/2026 TEJake TongesQuestionableSep 11: Coach Kyle Shanahan said after Thursday night's win over the Rams that Tonges' knee injury "does not look good," Vic Tafur of The Athletic reports.09/20/2026 WRKhaDarel HodgeQuestionableSep 30: Hodge (knee) did not practice Wednesday, Vic Tafur of The Athletic reports.10/04/2026 WRMike EvansQuestionableOct 26: Evans (Achilles) is expected to return after San Francisco's Week 8 bye, David Lombardi of SF Standard reports.11/08/2026 DENick BosaQuestionableOct 26: San Francisco head coach Kyle Shanahan said Monday that Bosa (knee) "has a chance" to return to action Nov. 8 versus the Raiders following a Week 8 bye, David Lombardi of SFStandard.com reports.11/08/2026 LBNick MartinQuestionableAug 22: Martin (hamstring) didn't participate in San Francisco's practice Saturday, Matt Maiocco of NBC Sports Bay Area reports.08/27/2026 CBUpton StoutQuestionableOct 26: Stout (shoulder) was only active as an emergency depth option during Sunday's loss to the Falcons, David Lombardi of SFStandard.com reported Monday.11/08/2026 OTAusten PleasantsInjured Reserve - Designated to ReturnAug 31: The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday.11/08/2026 
